Neuroinflammatory pathways in the human midcingulate cortex in Huntington’s disease
Mackenzie Ferguson, Thulani H Palpagama, Clinton Turner, Henry J Waldvogel, Richard L M Faull, Andrea Kwakowsky · FENS Forum 2024
Huntington’s disease (HD) is a genetic neurodegenerative disorder that can result in motor, mood and cognitive symptoms. HD pathophysiology has been linked to neuroinflammation, which is the presence of inflammatory mediators and reactive glial cells in the brain parenchyma. Many signalling pathways likely interact to propagate neuroinflammation and contribute to cell loss. Previous literature indicates that in the anterior cingulate cortex, cell loss and neuroinflammation are correlated with HD mood symptoms. This project gives insight into inflammation-related differential gene expression in
ePoster · Neuroscience