Targeting connexin hemichannels and the inflammasome response in an acute mouse model of Alzheimer’s disease
Aimee Mills, Aoife O’Connell, Monica Acosta, Colin Green, Helen Danesh-Meyer, Lola Mugisho, Andrea Kwakowsky · FENS Forum 2024
Pathologically activated connexin hemichannels can establish a self-propagating inflammasome activation loop that may contribute to Alzheimer’s disease (AD). This study aims to investigate the potential of modulating the inflammasome loop through connexin hemichannel blockade in a mouse model of AD known to display neurodegeneration, neuroinflammation, and memory deficits. One day after intrahippocampal injection of aggregated amyloid beta 1-42 (AB1-42), treatment mice (n=8) were administered a connexin hemichannel blocker, Tonabersat, in a peanut butter pellet for 16 days before tissue collec
ePoster · Neuroscience