Metformin administration mitigates early life stress-induced disruptions in hippocampal neurogenesis
Ekin Baysal, İrem İnanç, Deniz Billur, Esra Erdemli · FENS Forum 2024
Early Life Stress (ELS) can result in enduring health consequences, highlighting the need for exploring timely intervention approaches. Our study aims to investigate whether metformin, a long-recognized diabetes medication with neuroprotective and neurotrophic potential, can mitigate ELS-induced disruptions in hippocampal neurogenesis and dendritic growth. To test this hypothesis, both male and female neonatal Wistar rats were allocated into four distinct groups: control, metformin treatment, ELS model, and ELS model with metformin treatment (ELS+M). During the initial two weeks, ELS model was
ePoster · Neuroscience