Neuronal network dysfunction and neurodegeneration mediated by TLR7/8-activated microglia depend on the immunological context
Lennart Söder, Andrea Lewen, Amr Elgez, Babak Khodaie, Oliver Kann · FENS Forum 2024
Innate Toll-like receptors (TLRs) play a critical role in activating microglia in various diseases of the CNS. Our study aimed to examine the widely unknown consequences of stimulation of TLR7/8, which are known to recognize single-stranded RNA (ssRNA), e.g. from viruses. For this, we conducted electrophysiological local field potential recordings of neuronal gamma-oscillations (30-70 Hz), biochemical assays, and immunofluorescence in rat organotypic hippocampal slice cultures. Our findings reveal that single exposure (48 h) to the TLR7/8 agonist Resiquimod (R848) induces the release of pro-in
ePoster · Neuroscience