The effect of depleting the CNS border-associated macrophages at the pre-symptomatic stage of ALS on neuroinflammation, symptoms, and survival
Narges Shomalizadeh, Selçuk Polat, Judy Kesibi, Muhammet M. Ozturk, Sebastian A. Lewandowski, Esra Özkan, Yasemin Gürsoy Özdemir · FENS Forum 2024
Perivascular macrophages (PVMs) are a group of resident myeloid cells in the central nervous system (CNS) expressing the CD206 mannose receptor. They play dual roles: clearing harmful substances in healthy states and contributing to increased blood-brain barrier (BBB) in inflammatory states. To investigate their role in Amyotrophic lateral sclerosis (ALS) pathogenesis, we depleted PVMs at the presymptomatic stage in our ALS animal model and examined the effects on disease progression and neuroinflammation.In SOD1(G93A) mutated rats, PVM depletion was achieved via clodronate-loaded liposome int
ePoster · Neuroscience