Spatio-temporal dynamics of striatal astrocyte neurogenic activation after injury reveal widespread potential beyond known niches
Marco Fogli, Giulia Nato, Philip Greulich, Jacopo Pinto, Paolo Peretto, Annalisa Buffo, Federico Luzzati · FENS Forum 2024
In the adult mammalian brain neural stem cells (NSCs) are considered rare cells restricted to two specialised niches, the subventricular zone (SVZ) and the subgranular zone. Recent findings demonstrated that in response to injury new neurons can be generated also by parenchymal astrocytes, however the prevalence, distribution, and behaviour of these ectopic NSCs remained elusive. Consequently, the extent to which the neurogenic potential of the mature brain parenchyma differs from that of conventional neurogenic niches remains to be determined. To tackle this issue, here, we reconstructed the
ePoster · Neuroscience