Topic: closed-loop DBS

The freezing of gait (FOG) is a debilitating symptom of Parkinson’s disease (PD), which is resistant to dopamine replacement and deep brain stimulation (DBS) therapies, thus it is a clinical and scientific challenge. Modern DBS devices can record brain activity from chronically implanted electrodes, and animal models can be used to investigate motor network impairments at different biological scales. The combination of these tools posits a plethora of opportunities to identify gait-related biomarkers to improve gait therapy using closed-loop DBS in patients. Towards this goal, my PhD project a