Unifying fast and slow temporal dynamics of AMPARs during Long-Term Potentiation
Surbhit Wagle, Nataliya Kraynyukova, Maximilian Kracht, Anne-Sophie Hafner, Amparo Acker-Palmer, Erin Schuman, Tatjana Tchumatchenko · Bernstein Conference 2024
AMPA receptors (AMPARs) mediate fast excitatory neurotransmission and participate in memory formation. Synaptic strength is proportional to the number of AMPARs in the postsynaptic membrane. Previous models of AMPA receptor trafficking can explain their fast, brief incorporation in dendritic spines after LTP induction but offer limited insights into long-lasting changes in AMPAR content at potentiated spines[1,2]. Hence, a unified modeling framework is necessary to understand persistent synaptic changes in AMPAR numbers. Molecular trafficking, such as diffusion, active transport, endo/exocytos