Contactin-2: Myelination dynamics and synaptic plasticity in hippocampal interneurons
Sofia Petsangouraki, Delphine Pinatel, Edouard Pearlstein, Iason Sifakis, Evmorfia Vagiaki, Athanasia Voulgari, Manolis Agrymakis, Marina Vidaki, Kyriaki Sidiropoulou, Catherine Faivre-Sarrailh, Domna Karagogeos · FENS Forum 2024
Hippocampal Interneurons are heavily myelinated but show differences in composition/distribution and myelin function. Contactin-2 (CNTN2 or TAG-1), an adhesion molecule of the immunoglobulin superfamily, expressed in glia and axons, organizes the juxtaparanodal region of myelinated fibers and clusters voltage-gated potassium channels under the myelin sheath. CNTN2 has a dynamic spatial and temporal expression and is implicated in migration during development as well as in neuropathology (multiple sclerosis, AD). We have shown that a significant population of hippocampal GABAergic interneurons
ePoster · Neuroscience