Boosting myelination as a therapeutic strategy in autism
Maria Villafranca Faus, Almudena Robledo, Carla Peiro, Stefano Calovi, Alba Legarda, Laura Bayon-Cordero, Maria Victoria Sanchez-Gomez, Olga Peñagarikano, Maria Domercq · FENS Forum 2024
The neural basis of abnormal social behavior in autism spectrum disorder (ASD) remains incompletely understood and previous studies has highlighted that altered myelination could be involved in the pathophysiology of ASD. We have characterized the myelination process during development in the cntnap2-/- mouse model of ASD. We observed that oligodendrocyte differentiation and myelination are transiently impaired during cortical development in cntnap2-/- mice. Thus, we observed a reduction in myelinated fibers, the number of nodes of Ranvier and the proportion of mature oligodendrocytes in somat
ePoster · Neuroscience