Topic: cocaine-seeking behaviour

Addiction is a highly debilitating condition consisting of compulsive self-administration and seek for the substance of abuse, and its most challenging feature is the high rate of relapse. Addiction and relapse share similarities with a brain process called neural plasticity which acts through the Brain-Derived Neurotrophic Factor and its receptor TrkB. Moreover, Somatostatin (SST) expressing interneurons are involved in neuronal plasticity and are important in modulating cocaine-seeking behaviour in mice.We are testing the role of TrkB in Somatostatin(SST)-expressing neurons in the formation