The role of cytoskeletal proteins ADF/Cofilin1 in microglia morphology and function
Marie Denise Roggan, Sophie Crux, Felix Nebeling, Fabrizio Musacchio, Stefanie Poll, Juliane Schiweck, Manuel Mittag, Julia Steffen, Andrea Baral, Yvonne Schleehuber, Frank Bradke, Walter Witke, Martin Fuhrmann · FENS Forum 2024
Microglia, the immune cells of the central nervous system, are important for tissue homeostasis and in response to disease. Additionally, they are crucial during brain development, promote synapse elimination and survival, thereby even contributing to higher brain functions like cognition. Microglia are highly motile cells that continuously survey the brain parenchyma by extending and retracting their fine processes, yet the molecular mechanisms governing their dynamic shape changes are not fully understood.The cytoskeletal proteins actin depolymerizing factor and cofilin 1 (ADF/Cfl1) have est
ePoster · Neuroscience