Effects of cognitive and multidimensional enrichment on the synaptic impairments of the PINK1 and ASYN mouse models of Parkinson’s disease
Ilham El Atiallah, Martina Montanari, Giulia Ponterio, Francesca Balsamo, Eugenia Landolfo, Robert A. Rissman, Francesca Gelfo, Paola Bonsi · FENS Forum 2024
Parkinson's disease (PD) is a progressive neurodegenerative disorder, characterized by resting tremor, rigidity, and bradykinesia. Additionally, a wide spectrum of early non-motor symptoms has been described, among which cognitive impairment is one of the most relevant.Several studies show that interventions focused on cognitive stimulation can play an important role in preventing or delaying the onset of dementia in patients with neurodegenerative diseases. In this perspective, we aimed at investigating the synaptic mechanisms mediating the effects of cognitive enrichment in two mouse models
ePoster · Neuroscience