Effects of a downregulation of mTORC1’s pathway in D2R cells of nucleus accumbens on impulsive behavior in rats
Fanny Joly, Robin Magnard, Alessandra Russolillo, Yvan Vachez, Frédérique Vossier, Carole Carcenac, Sabrina Boulet, Emmanuel Valjent, Sebastien Carnicella · FENS Forum 2024
Impulse control disorders (ICDs) are characterized by irresistible urges to act without foresight and an impaired inhibition of these behaviors, which constitute an important feature of substances or behavioral addictions, such as gambling, hypersexuality, or compulsive eating. In Parkinson’s disease patients, dopaminergic D2-receptor (DA D2R) agonist treatment pramipexole (PPX) has been shown to trigger ICD’s for 2/3 of them, highlighting the involvement of DA transmission in ICDs onset, especially through the D2R family.Striatal D2R transmission is acting principally through the indirect pat
ePoster · Neuroscience