Topic: cognitive side effects

Ketamine is a rapid-acting antidepressant often accompanied with different cognitive side effects. Previous research has generated mixed results regarding its effects on distinct types of memory. Here, we investigated the effects of an antidepressant dose (10 mg/kg) of ketamine on encoding, retrieval, and modulation processes in an implicit and an explicit memory task in adult male Wistar rats (n = 60). Ketamine (IP) was administered 30 minutes either before the acquisition, retrieval, or extinction phase of auditory fear conditioning (implicit task). Similarly, different groups of animals rec