Impaired glymphatic clearance in schizophrenia
Moritz Bonhoeffer, Viktor Neumaier, Melissa Thalhammer, Julia Schulz, Christine Preibisch, Sibylle Ziegler, Matthias Brendel, Igor Yakushev, Josef Priller, Christian Wachinger, Fabian Bongratz, Markus Karmann, Dennis Hedderich, Felix Brandl, Benedikt Zott, Christian Sorg · FENS Forum 2024
According to the model of the glymphatic system, the clearance of waste products from the brain is dependent on the directed flow of fluid across different compartments in the brain and associated lymphatic vessels. The coupling between the coherent global grey matter activity (gGM-activity) and cerebrospinal fluid movement (gGM-CSF-coupling) is thought to drive glymphatic fluid movement in humans. Since gGM-coherence is severely impaired in patients with schizophrenia, the glymphatic system might be impaired in the disorder. Therefore, we hypothesized aberrant glymphatic function in schizophr
ePoster · Neuroscience