Effects of early handling and sex on cognitive resilience in APP/PS1 mice
Maria Carrigan, Jeniffer Sanguino-Gómez, Wiesje M. van der Flier, Paul J. Lucassen, Rik Ossenkoppele, Harm J. Krugers · FENS Forum 2024
Aggregation of amyloid-beta (Aβ) is among the earliest pathological changes in Alzheimer's disease (AD, Kamenetz et al., 2003). In some individuals, however, memory and other cognitive functions remain intact, despite the presence of abundant Aβ pathology (Stern, 2012). This suggests that neurons and networks can recruit mechanisms that protect against Aβ pathology, a concept known as cognitive resilience (CR). Notably, this occurs in a sex-dependent manner, with greater CR in females (Buckley et al., 2019, Ossenkoppele et al., 2020).The underlying mechanisms of resilience to AD pathology rema
ePoster · Neuroscience