Amyloid-β predicts oscillatory slowing and reduced functional connectivity over time in cognitively unimpaired adults
Elliz Scheijbeler, Willem De Haan, Emma Coomans, Anouk Den Braber, Jori Tomassen, Mara Ten Kate, Elles Konijnenberg, Lyduine E. Collij, Elsmarieke Van de Giessen, Frederik Barkhof, Pieter-Jelle Visser, Cornelis J. Stam, Alida A. Gouw · FENS Forum 2024
Amyloid-beta (Aβ)-induced changes in neuronal activity could yield valuable early markers of Alzheimer’s disease (AD). The neurophysiological manifestations associated with early Aβ-pathology in humans are however not well defined. This study investigated the relationship between Aβ-pathology and neurophysiological characteristics in 110 cognitively unimpaired individuals (65.9±5.7 years). All subjects underwent 18F-flutemetamol-PET imaging and resting-state magnetoencephalography (MEG) recording at baseline and 4-year follow-up. We tested associations between baseline Aβ-binding potentials (B
ePoster · Neuroscience