Neuronal SMC3 regulates weight, body composition, and hormonal balance in parallel with sex-dependent effects on anxiety behavior
Saleev Natalia, Bartman Joanna, Getselter Dmitriy, Gutman Roey, Marco Asaf, Evan Elliott · FENS Forum 2024
SMC3 is a major component of the cohesin complex that regulates higher-order chromatin organization and gene expression. Human genetic studies reveal de novo mutations in SMC3 gene, found in patients with Cornelia de Lange syndrome (CdLs). This syndrome is characterized by intellectual disabilities, and behavioral patterns such as self-injury, and metabolic dysregulation. Nonetheless, little is known about the exact role of SMC3 in neuronal maintenance and gene expression especially in adulthood. This study aimed to determine the role of SMC3 in adulthood brain, using in-vivo models of adultho
ePoster · Neuroscience