Topic: cold pain

The sensation of cooling appears to depend largely on the transient receptor potential channel TRPM8. However, the detection of noxious cold is still controversial. Many targets have been proposed for the transduction of cold into an electrical signal. So far, there is no experimental human model that allows the application of potential antagonists at the same site as the cold. This is further complicated by the fact that the site of cold transduction is unclear.We have developed a human pain model based on intradermal injection of cooled extracellular solution into the volar forearm. This is