Topic: cold-sensing nerve endings

This study is aimed to understand sensory nerve endings’ functional organization and morphology in the adult mouse cornea. Free nerve endings are essential for the sensory transduction of noxious and innocuous stimuli. However, their functional organization still needs to be fully understood. To investigate this, we used GCaMP6s-based in vivo imaging of calcium signals evoked by menthol and capsaicin in corneal nerve endings of 5-6 week-old C57 mice (Fig. 1A). We then acquired 3D confocal images of their morphological structure and examined the contribution of voltage-gated calcium channels (V