Identifying the biological relationship among the stages and patterns of cocaine addiction and behaviors that predict drug abuse
Jason Bubier, Troy Wilcox, Vivek Phillip, He Hao, Michael Saul, Price Dickson, Lisa Tarantino, David Jentsch, CSNA Phenotyping Team, Elissa Chesler · FENS Forum 2024
Substance use disorders (SUD) remain among the most poorly managed health conditions owing to the lack of effective management tools and treatment. Among substances that are used unhealthily, cocaine has the highest genetic heritability (>70%). The advanced mouse resources of the Collaborative Cross and Diversity Outbred (DO) population are a complementary group of mice that allow for a systems genetic analysis of heritable traits. As part of a NIDA Center for Excellence, we have phenotyped 973 DO mice using the cocaine intravenous self-administration (IVSA) paradigm, the gold standard para
ePoster · Neuroscience