Blood-spinal cord barrier alterations in a mouse model of centrifugation-induced hypergravity
David Dubayle, Nicolas Rebergue, Yann Godfrin, Jean-Luc Morel, Sighild Lemarchant · FENS Forum 2024
Astronauts endure repetitive episodes of hypergravity (HG) during takeoff and landing of spaceflights, and also in space due to microgravity. We have recently shown subtle BBB breakdown in a mouse model of centrifugation-induced HG (Dubayle et al., 2023); here we have evaluated if the blood-spinal cord barrier (BSCB) was also damaged in this model.Eight-week-old C57Bl/6J male mice were subjected to HG in a centrifuge at 2g for 24h, while control mice stayed in normogravity (N=9/group). Mice were sacrificed after centrifugation, and thoracic spinal cords collected for immunohistochemistry. For
ePoster · Neuroscience