Topic: collicular inputs

Spinal cord-projecting neurons in the rostral ventromedial medulla (RVMSC neurons) play active roles in pain facilitation. However, the underlying circuitry and molecular mechanisms remain largely unknown. We show that acute activation of OPRM1+ RVMSC neurons does not facilitate pain in normal mice, but activity of these neurons is required for both initiation and maintenance of chronic mechanical hypersensitivity in mouse models of inflammatory and neuropathic pain. Excitatory collicular inputs are essential for upregulating pseudokinase CaMKv in the OPRM1+ RVMSC neurons after nerve injury an