Primary sensory neurons require a functional interleukin-6 signal transducer to regulate gut microbiota composition in mice
Lydia Riehl, Johannes Fürst, Susanne K. Sauer, Kai Kummer, Nadiia Rykalo, Theodora Kalpachidou, Michaela Kress · FENS Forum 2024
Interleukin 6 (IL-6), its receptor (IL-6R), with the IL-6 signal transducer gp130 (IL-6ST) are well known regulators of innate immunity but also affect neuron morphology and function. More recent evidence suggests that they also play a significant role in shaping microbiota composition and gut-barrier function (1). However, the exact pathways and mechanisms are still elusive. We therefore investigated the involvement of functional IL-6 signaling in the bilateral communication between primary afferent neurons and gut microbiota.Transgenic mice with a conditional depletion of gp130 in neurons ex
ePoster · Neuroscience