Olfactory ensheathing cells and fibroblasts: Dynamic partners in nervous system repair and regeneration
Francesca Oieni, Ronak Reshamwala, Megha Shah, Joshua Ingles, Jenny A K Ekberg, James St John · FENS Forum 2024
Olfactory ensheathing cells (OECs) transplantation is emerging as promising nerve repair therapy, particularly for spinal cord injury (SCI), owing to their intrinsic regenerative capacity within the olfactory system. Perineural fibroblasts are natural partners of OECs within the olfactory nerve and co-transplantation with OECs may improve transplantation repair outcomes. However, little is known about the natural interactions of OECs and fibroblasts during the chaotic state following an injury. Using a mouse model, we temporarily damaged the olfactory nerves using methimazole. At key stages of
ePoster · Neuroscience