Generation of combinoids to study Parkinson’s disease in a 3D in vitro and in vivo system
Serena Viventi, Frausin Stefano, Dad Abu-Bonsrah, Charlotte Ermine, Tyra Fraser, Clare Parish, Lachlan Thompson · FENS Forum 2024
Parkinson’s disease (PD) is a neurodegenerative disorder characterized by the progressive degeneration of midbrain dopamine neurons. Current treatments mainly rely on pharmacotherapy, which seems to provide beneficial effects only in the very early stages of the disease. Having an in vitro source of mature midbrain dopamine neurons from patients is paramount to initially reproduce disease phenotypes and subsequently identify disease-modifying drug candidates. In this context, three-dimensional (3D) induced pluripotent stem cell (iPSC)-derived brain organoids play an important role, as they mim
ePoster · Neuroscience