A stable sensory map emerges from neurons with unstable tuning properties
Dominik Aschauer, Anna Chambers, Jens-Bastian Eppler, Matthias Kaschube, Simon Rumpel · COSYNE 2023
Primary sensory cortices are functionally organized according to topographic principles, such as the tonotopic map of auditory cortex. Recently, chronic recordings of neuronal activity have revealed that single cell stimulus tuning can undergo continuous remodeling, which appears to be in conflict with the stability of sensory maps. Using longitudinal two-photon imaging in the auditory cortex of 12 mice (21.506 neurons), we attempt to reconcile the conflicting observations of unstable single-cell tuning properties and stable population-level topographic maps. Using intrinsic imaging and chroni
Sat, Mar 11, 2023