Cholinergic regulation of dendritic Ca2+ spikes controls firing mode of hippocampal CA3 pyramidal neurons
Noémi Kis, Balázs Lükő, Judit Herédi, Ádám Magó, Bela Erlinghagen, Mahboubeh Ahmadi, Snezana Raus Balind, Mátyás Irás, Balázs B. Ujfalussy, Judit K. Makara · FENS Forum 2024
The hippocampus is essential for spatial navigation and memory processes. Hippocampal pyramidal cells (PCs) often exhibit complex spike bursts (CSBs) that are driven by regenerative dendritic Ca2+ plateau potentials. These events can induce rapid synaptic plasticity and new place field (PF) formation in CA1PCs. CA3PCs also fire CSBs, and their PF-inducing CSBs were shown to be particularly prolonged (Li et al, bioRxiv). However, the dendritic mechanisms underlying such long-lasting events in CA3PCs remain unclear. In acute rat brain slices, we observed large heterogeneity among CA3PCs in CSB p
ePoster · Neuroscience