Maternal separation modifies the stress sensitivity, electrophysiology, and morphology of rat nucleus incertus neurons
Anna Gugula, Patryk Sambak, Aleksandra Trenk, Sylwia Drabik, Aleksandra Nogaj, Zbigniew Soltys, Andrew L. Gundlach, Anna Blasiak · FENS Forum 2024
Early-life stress (ELS) disrupts brain development and predisposes sufferers to stress-related disorders and compulsive behaviour in adulthood. Accumulating evidence connects these disorders with neurons within the stress-sensitive, brainstem nucleus incertus (NI), which synthesize the neuropeptides, relaxin-3 (RLN3) and cholecystokinin (CCK). Although NI RLN3 neurons are implicated in stress responses, arousal and drug-seeking behaviour, their vulnerability to stress during development has not been explored, and little is known about NI CCK neurons. Therefore, this study investigated the infl
ePoster · Neuroscience