Topic: compulsive-like seeking

One of the major challenges of addiction research is to identify vulnerable individuals before they develop addictive disorders. Indeed, only a small subset of users (20-30%) develop pathological behaviors such as loss of control over drug use and compulsive seeking/consumption of the substance despite the negative consequences. In rats, pathological low frequency oscillations in the subthalamic nucleus (STN) can predict compulsive-like cocaine seeking. However, the deep location of this predictive biomarker, requiring invasive electrode implantation, prevents its potential use in humans. Thus