Topic: compulsive overeating

Obesity is driven and maintained by dysregulation of appetite. Especially nowadays, with rich availability of palatable processed food, overeating promotes weight gain through unbalancing energy expenditure and intake. Lifestyle interventions are foundation of obesity management; however, the long-term maintenance is challenging. Thus, understanding the neural mechanism underlying compulsive overeating is urgent for better weight control. Dopamine system and hypothalamus are highly involved in obesity, proved by fMRI in patients. In mice, our lab discovered that a specific subset of nucleus ac