Subchronic administration of the antidiabetic drug metformin mitigates cognitive impairments in a mouse model of type 2 diabetes mellitus
Edoardo Pisa, Martina Presta, Angela Maria Ottomana, Simone Macrì · FENS Forum 2024
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder marked by hyperglycemia, hyperinsulinemia, and altered insulin signaling. Current investigations propose that insulin not only participates in general metabolic processes but also exerts influence over brain functions. Also, altered insulin signaling is observed in conditions like Alzheimer's Disease and Obsessive-Compulsive Disorder. Despite evidence, current treatments targeting insulin signaling lack validation for mental disorders. Understanding insulin's role in concurrent mental and somatic disorders may reveal strategies fo
ePoster · Neuroscience