Low action potential firing threshold facilitates "in-out" function of fast-spiking interneurons in the human neocortex
Emőke Bakos, Ádám Tiszlavicz, Viktor Szegedi, Abdennour Douida, Daphne Welter, Jonathan Landry, Pál Barzó, Gábor Tamás, Vladimir Benes, Attila Szűcs, Karri Lamsa · FENS Forum 2024
The neocortex is built up from homologous neuron types, but neurons exhibit between-species differences in gene expression, molecular profile, and electrical function. Purpose of these specializations is not well understood. In human neocortex, fast-spiking interneurons have high electrical excitability compared to their rodent counterparts. This slows down time course for cell membrane potential changes, and in theory, makes human fast-spiking neurons slower than rodent cells to process electrical input signals and generate action potential (AP). However, human neurons are nearly as fast with
ePoster · Neuroscience