Aberrant generation of granular cells in the dentate gyrus, due to p53 deletion, is associated with epilepsy susceptibility in mice
Nuria Ruiz Reig, Georges Chehade, Xavier Yerna, Irene Durá, Philippe Gailly, Fadel Tissir · FENS Forum 2024
Neuronal apoptosis is a mechanism used to clear the cells of oxidative stress or DNA damage and to refine the final number of neurons for a functional neuronal circuit. The tumour suppressor protein p53 is a key regulator of the cell cycle and serves as a checkpoint for eliminating neurons with high DNA damage, aberrant hyperproliferative signals or cellular stress. Meanwhile p53 is largely expressed in progenitors’ cells during development, in adult mice p53 expression is restricted to the neurogenic niches where it regulates cell proliferation and self-renewal. To investigate the functional
ePoster · Neuroscience