Motor and memory deficits in nestin-Cre Psip1 KO mice
Laura Debusschere, Eduard Bentea, Siska Van Belle, Yannick Hoogvliets, Nam Joo Van der Veken, Martine Michiels, Chris Van den Haute, Veerle Baekelandt, Zeger Debyser · FENS Forum 2024
Lens epithelium-derived growth factor (LEDGF), encoded by the Psip1 gene, is present throughout the body in two splice variants, LEDGF/p75 and LEDGF/p52. Histological analysis of fetal and adult human brains suggests a role in neurogenesis and differentiation of neuroepithelial stem cells. Furthermore, binding partners of LEDGF/p75, e.g. MeCP2 and PogZ are implicated in neurological diseases. To study the role of LEDGF in the brain, we developed a conditional Psip1 knock-out (KO) mouse model by crossbreeding Psip1Fl/Fl (doi:10.1101/gad.1565107) mice with nestin-Cre transgenic mice, resulting i
ePoster · Neuroscience