Topic: conditioned suppression of reward seeking

Basolateral amygdala (BLA) principal neurons form distinct long-range circuits that mediate negative (via projections to the central amygdala) and positive (via projections to the nucleus accumbens) valence (Namburi et al., 2015). In a series of experiments using rats, we investigated the roles of these BLA pathways in Pavlovian fear learning. First, consistent with past work in mice, retrograde tracing showed that the two pathways were largely segregated; but, in contrast to past work in mice, single molecule FISH showed that these two pathways shared similar molecular profiles. Then, we used