Topic: congenital thyroid hypoplasia

Persistent organic pollutants like dioxin, PCBs, PFOS, PFOA, and brominated flame retardants are known to disrupt thyroid hormones. Previous animal studies have reported their effects on activity and cognitive functions. Our research group utilizes IntelliCage, an automated behavior recording system, to assess exposure effects of metals such as arsenic, methylmercury, and dioxins. In this study, we investigated how hypothyroidism induces behavioral abnormalities in growth-retarded (grt) mice with congenital thyroid hypoplasia. Grt mice, characterized by a tyrosylprotein sulfotransferase 2 (Tps