Hard to digest: The challenges of modeling the dynamics of the C. elegans pharynx
James Ferguson, Tim P Vogels · FENS Forum 2024
The last decade has brought us riches of connectomes from several species. Even though these detailed snapshots provide substantial insight into structure, composition and connectivity of neural networks, they fall short of explaining the dynamics they support. This stems from the difficulty to derive cellular model parameters, e.g., cell type and synaptic strengths, from fixed tissue. Additionally, neural systems are often governed by so-called ‘wireless’ connectivity, i.e., neuromodulation, controlling network state by way of volumetrically dispensed transmitters. What we can learn from a co
ePoster · Neuroscience