Chronodisruption during early developmental stages affects clock in the SCN in a sex-dependent manner via melatonin-independent signaling pathways
Kateryna Semenovykh, Petra Honzlová, Dmytro Semenovykh, Tereza Dočkal, Martin Sládek, Pavel Houdek, Philipp Greiner, Alena Sumová · FENS Forum 2024
Disruption of circadian regulation, particularly during the early developmental stages (EDS), can have deleterious, long-lasting effects. Previous studies have shown that melatonin is involved and that susceptibility to chronodisruption in rats is sex-dependent. Our aim was to investigate the effect of chronodisruption via constant light (LL) during EDS on the clock in the suprachiasmatic nucleus (SCN) of male and female mice naturally deficient in melatonin. We used PER2::LUC knock-in mice, which allows monitoring of clock function in organotypic explants ex vivo. First, we showed that the SC
ePoster · Neuroscience