Topic: constrained non-negative matrix factorization

Anatomically segregated apical and basal dendrites of pyramidal neurons receive functionally distinct inputs, but it is unknown if this results in compartment-level functional diversity. Hippocampal place cells exhibit representational drift (Ziv et al., 2013), but this has only been characterized with somatic recordings. While dendritic activity is implicated in the formation of stable place fields and shaping hippocampal activity, in vivo studies of hippocampal dendritic activity have largely been confined to basal dendrites (Sheffield and Dombeck, 2015) or small cross-sections of apical den