Topic: Contactin-associated protein 2

Autoantibodies (aAb) targeting Contactin-associated protein 2 (Caspr2) have been implicated in neuropathic pain, yet the precise underlying pathomechanism is not completely understood. Caspr2 is part of a protein complex named the voltage-gated potassium channel (VGKC) complex located at the juxtaparanodal region of the nodes of Ranvier in the peripheral nervous system. Dorsal root ganglia (DRG) may serve as mediating neurons transmitting nociceptive signals from the periphery to the central nervous system. Therefore, changes in the excitability of DRG neurons might contribute to the pathology