Lateralization of motor responses following focused ultrasound neuromodulation of the motor cortex and thalamus in awake mice
Jonas Bendig, David Sulzer, Elisa E. Konofagou · FENS Forum 2024
Focused ultrasound (FUS) is a novel noninvasive modality for neuromodulation in the central nervous system with a high spatial resolution and the ability to target deep brain structures. Rodent studies have shown motor responses following FUS but mostly failed to demonstrate consistent and target-specific effects. Here, we used a high-frequency (4 MHz) transducer with a small focal area to investigate the target-specificity of FUS neuromodulation. Mice were implanted with a large cranial window consisting of an ultrasound-transparent Polymethylpentene membrane. For the experiment, awake mice w
ePoster · Neuroscience