Carbon monoxide as potent modulator of pain- and anxiety-related behavior in experimental chronic pelvic pain syndrome
Nikola Šutulović, Milena Vesković, Dušan Mladenović, Željko Grubač, Yavuz Dodurga, Mucahit Seçme, Đuro Macut, Aleksandra Rašić Marković, Olivera Stanojlović, Dragan Hrnčić · FENS Forum 2024
Chronic pelvic pain syndrome (CP/CPPS) is frequently accompanied by brain-related comorbidities including anxiety, but the mechanisms of this relationship are far from being elucidated. Having in mind that gaseous neurotransmitter CO signaling could be included in anxiogenesis, we hypothesized that some of the anxiety states in CPPS could be attributed to CO signaling. Therefore, this study aimed to investigate the effects of CORM-A1 (slow realizing CO donor) on anxiety-related behavior and pain sensitivity in rats with experimentally induced CP/CPPS. CP/CPPS was induced in male rats by 3% λ-c
ePoster · Neuroscience