Corneal TRPA1 nociceptor: A regulator of neurogenic inflammation in a mouse model of dry eye
Tiffany Migeon, Tristan Hourcade, Anaïs Potey, Céline Olmière, Christophe Baudouin, Annabelle Réaux-Le Goazigo, Stéphane Mélik-Parsadaniantz · FENS Forum 2024
Dry eye disease (DED) involves neurosensory abnormalities and inflammation. The aim of this study was to elucidate the role of transient receptor potential ankyrin-1 (TRPA1), a highly expressed corneal nociceptor, in neurogenic inflammation associated with persistent DED.Multi-unit extracellular recording of naive mice ciliary nerve was monitored with/without TRPA1 antagonist (HC030031), to determine which corneal nerve fiber is inhibited by this antagonist. DED was induced in mice by removing the extraorbital lacrimal gland and Harderian gland. Mice underwent topical treatment with HC030031 o
ePoster · Neuroscience