Hand preference switching with intra- and inter-hemispheric cholinergic modulation
Kazuki Okamoto, Yasuhiro Tanaka, Shigeki Kato, Kazuto Kobayashi, Masato Koike, Hiroyuki Hioki · FENS Forum 2024
Lateralization of motor skills such as hand preference is a common trait across various species, including humans and rodents. It's well known that humans can alter their dominant hand through training, a process often associated with psychological stress and the potential for developmental issues, including language impairments. Yet, the neural mechanisms underlying the hand switching remain largely obscure. Our research delves into this phenomenon in mice, revealing that they can also alter their hand preference via corrective training. We focused on the basal forebrain's cholinergic system,
ePoster · Neuroscience