Organizing the coactivity structure of the hippocampus from robust to flexible memory
Giuseppe Pietro Gava, Laura Lefèvre, Tabitha Broadbelt, Stephen McHugh, Vitor Lopes-dos-Santos, Demi Brizee, Katja Hartwich, Hanna Sjoberg, Pavel Perestenko, Robert Toth, Andrew Sharott, David Dupret · FENS Forum 2024
New memories are integrated into prior knowledge of the world. But what if consecutive memories exert opposing demands on the host brain network? We report that acquiring a robust (food-context) memory constrains the hippocampus within a population activity space of highly correlated spike trains that prevents subsequent computation of a flexible (object- location) memory. This densely correlated firing structure developed over repeated mnemonic experience, gradually coupling neurons of the superficial CA1 pyramidale sublayer to whole population activity. Applying hippocampal theta-driven clos
ePoster · Neuroscience