Development and reorganization of hippocampal representations during contextual spatial learning
Rita Nyilas, Balázs Lükő, Atilla B Kelemen, Balázs B Ujfalussy, Judit K Makara · FENS Forum 2024
The hippocampus supports flexible navigation by creating context-dependent spatial maps. How these maps emerge during learning and change upon manipulation of the context is not well understood. To elucidate these dynamics, we studied CA1 pyramidal cell (PC) representations in a contextual go/no-go task.We trained water-restricted, head-fixed Thy1-GCaMP6s mice to run on a treadmill in virtual environments, and distinguish two visually distinct corridors by selectively licking in a reward zone in one corridor. We monitored CA1PC activity by two-photon Ca2+ imaging and assessed behavior by measu
ePoster · Neuroscience