Mitochondrial dysfunction underlies impaired neurovascular coupling following traumatic brain injury
Gerben Van Hameren, Jamil Muradov, Anna Minarik, Refat Aboghazleh, Sophie Orr, Mark Maclean, Alon Friedman · FENS Forum 2024
Traumatic brain injury (TBI) involves an acute injury (primary damage), which may evolve in the hours to days after impact (secondary damage). Cortical spreading depolarization (CSD) is a metabolically demanding processes that may worsen the secondary brain injury. Metabolic stress has been associated with mitochondrial dysfunction, including impaired calcium homeostasis and elevated ROS production. However, the association between mitochondrial impairment and vascular function after TBI is poorly understood. We therefore aimed to 1) Identify the role of CSD on neurological outcome after TBI,
ePoster · Neuroscience