Cortical-bulbar feedback supports behavioral flexibility during rule reversal
Diego Eduardo Hernández Trejo, Andrei Ciuparu, Pedro Garcia da Silva, Cristina Velázquez, Raul Mureşan, Dinu Albeanu · COSYNE 2023
Animals flexibly adjust their behavior to adapt to environmental changes. Mice excel at recognizing odorants in complex sensory conditions; however, little we know about: (1)how sudden changes in stimulus contingency modify odorant representations and (2)how changes in odorant representations causally relate to behavioral adjustments. The olfactory bulb(OB) relays odor-triggered information to higher olfactory areas, including the piriform cortex(PCx). The PCx receives input from association areas(e.g., orbitofrontal cortex) and sends dense feedback that selectively modulates one of the OB out
Fri, Mar 10, 2023